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KMID : 1101320130450030102
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Korean Journal of Clinical Laboratory Science
2013 Volume.45 No. 3 p.102 ~ p.107
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Seroprevalence of Antibody to Hepatitis A Virus in North-West Jeonbuk Province
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Shin Yong-Sub
Kim Yoo-Hyun
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Abstract
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Hepatitis A (HA) is an acute infectious disease of the liver caused by the Hepatitis A virus (HAV). In acute HA, the presence of anti-HAV IgM is detectable and about 3 weeks after exposure, its titre increases over 4 to 6 weeks. Anti-HAV IgG is detectable within a few days of the onset of symptoms. IgG antibodies continue to last for years after infection and provide lifelong immunity to the host. This study was performed to investigate the current seroprevalence of anti-HAV antibodies in Jeonbuk province, South Korea. A total of 591 (male 322, female 269) serum samples were collected in July 2011 to June 2012. We tested the antibodies of anti-HAV IgG and IgM using a Modular E170 (Roche Diagnostics, Germany), and analysed the serum alanine aminotransferase (ALT) levels by HITACH 7600-100 (HITACH, Japan). The overall seroprevalence of anti-HAV IgG was 84.6% (500/591), and the rate of females (85.9%) was higher than males (83.5%). According to the decade of age, seroprevalence of anti-HAV IgG were as follows; 68.8% (11/16) in the under 10 years old category, 100% (19/19) in the 10∼19 category, 96% (48/50) in the 20∼29 category, 83.6% (56/67) in the 30∼39 category, 84.3% (123/146) in the 40∼49 category, 83.3% (135/162) in the 50∼59 category, 83.1% (54/65) in the 60∼69 category, 78.1% (32/41) in the 70 ∼79 category, and 88% (22/25) in the over 80 category. Total seroprevalence of anti-HAV IgM was 3.4% (20/591), and according to gender, the seroprevalence of male (3.1%) was very similar to that of female (3.7%). Through this study, we know that the seroprevalence of anti-HAV antibody in north-west Jeonbuk province, South Korea, was high. Only children under the age of 10 remain susceptible to HAV infection. Vaccination against HAV is not needed at the present time for the people of Jeonbuk province, South Korea, but a vaccination should be recommended and the improvement in sanitary conditions and personal hygiene should be highlighted.
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KEYWORD
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Hepatitis A, Anti-HAV, Seroprevalence, Jeonbuk province, Vaccination
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